@article{fdi:010082794,
  title = {{B}leeding and thrombosis : insights into pathophysiology of bothrops venom-related hemostasis disorders},
  author = {{L}arreche, {S}. and {C}hippaux, {J}ean-{P}hilippe and {C}hevillard, {L}. and {M}athe, {S}. and {R}esiere, {D}. and {S}iguret, {V}. and {M}egarbane, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}oxins from {B}othrops venoms targeting hemostasis are responsible for a broad range of clinical and biological syndromes including local and systemic bleeding, incoagulability, thrombotic microangiopathy and macrothrombosis. {B}eyond hemostais disorders, toxins are also involved in the pathogenesis of edema and in most complications such as hypovolemia, cardiovascular collapse, acute kidney injury, myonecrosis, compartmental syndrome and superinfection. {T}hese toxins can be classified as enzymatic proteins (snake venom metalloproteinases, snake venom serine proteases, phospholipases {A}(2) and {L}-amino acid oxidases) and non-enzymatic proteins (desintegrins and {C}-type lectin proteins). {B}leeding is due to a multifocal toxicity targeting vessels, platelets and coagulation factors. {V}essel damage due to the degradation of basement membrane and the subsequent disruption of endothelial cell integrity under hydrostatic pressure and tangential shear stress is primarily responsible for bleeding. {H}emorrhage is promoted by thrombocytopenia, platelet hypoaggregation, consumption coagulopathy and fibrin(ogen)olysis. {O}nset of thrombotic microangiopathy is probably due to the switch of endothelium to a prothrombotic phenotype with overexpression of tissue factor and other pro-aggregating biomarkers in association with activation of platelets and coagulation. {T}hrombosis involving large-caliber vessels in {B}. lanceolatus envenomation remains a unique entity, which exact pathophysiology remains poorly understood.},
  keywords = {snake venom ; hemorrhage ; microthrombi ; thrombocytopenia ; coagulopathy},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {M}olecular {S}ciences},
  volume = {22},
  numero = {17},
  pages = {9643 [26 ]},
  year = {2021},
  DOI = {10.3390/ijms22179643},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082794},
}