@article{fdi:010082748,
  title = {{A}ncient divergence of {I}ndian and {T}ibetan wolves revealed by recombination-aware phylogenomics},
  author = {{H}ennelly, {L}. {M}. and {H}abib, {B}. and {M}odi, {S}. and {R}ueness, {E}. {K}. and {G}aubert, {P}hilippe and {S}acks, {B}. {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he grey wolf ({C}anis lupus) expanded its range across {H}olarctic regions during the late {P}leistocene. {C}onsequently, most grey wolves share recent (<100,000 years ago) maternal origins corresponding to a widespread {H}olarctic clade. {H}owever, two deeply divergent (200,000-700,000 years ago) mitochondrial clades are restricted, respectively, to the {I}ndian subcontinent and the {T}ibetan {P}lateau, where remaining wolves are endangered. {N}o genome-wide analysis had previously included wolves corresponding to the mitochondrial {I}ndian clade or attempted to parse gene flow and phylogeny. {W}e sequenced four {I}ndian and two {T}ibetan wolves and included 31 additional canid genomes to resolve the phylogenomic history of grey wolves. {G}enomic analyses revealed {I}ndian and {T}ibetan wolves to be distinct from each other and from broadly distributed wolf populations corresponding to the mitochondrial {H}olarctic clade. {D}espite gene flow, which was reflected disproportionately in high-recombination regions of the genome, analyses revealed {I}ndian and {T}ibetan wolves to be basal to {H}olarctic grey wolves, in agreement with the mitochondrial phylogeny. {I}n contrast to mitochondrial {DNA}, however, genomic findings suggest the possibility that the {I}ndian wolf could be basal to the {T}ibetan wolf, a discordance potentially reflecting selection on the mitochondrial genome. {T}ogether, these findings imply that southern regions of {A}sia have been important centers for grey wolf evolution and that {I}ndian and {T}ibetan wolves represent evolutionary significant units ({ESU}s). {F}urther study is needed to assess whether these {ESU}s warrant recognition as distinct species. {T}his question is especially urgent regarding the {I}ndian wolf, which represents one of the world's most endangered wolf populations.},
  keywords = {{C}anidae ; {C}anis lupus ; gene flow ; grey wolf ; phylogenomics ; recombination ; {INDE} ; {TIBET}},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {30},
  numero = {24},
  pages = {6687--6700},
  ISSN = {0962-1083},
  year = {2021},
  DOI = {10.1111/mec.16127},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082748},
}