Jacob C. G. auteur aut IRD Thuy-Nhien N. auteur aut IRD Mayxay M. auteur aut IRD Maude R. J. auteur aut IRD Quang H. H. auteur aut IRD Hongvanthong B. auteur aut IRD Landier Jordi auteur aut IRD et al. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures. Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs. Results: GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs. Conclusions: GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community. specialized VIET NAM LAOS CAMBODGE THAILANDE BANGLADESH 052 020 10 e62997 [22 p.] 2021 2050-084X https://www.documentation.ird.fr/hor/fdi:010082685 10.7554/eLife.62997 2050-084X [F B010082685] https://www.documentation.ird.fr/hor/fdi:010082685 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-09/010082685.pdf IRD - Base Horizon / Pleins textes 2021-09-17 2025-02-24 fdi:010082685 fre