@article{fdi:010082679,
  title = {{M}etallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells},
  author = {{C}ano, {L}. and {B}ertani, {S}t{\'e}phane and {I}sland, {M}. {L}. and {C}erapio, {J}. {P}. and {R}uiz, {E}. and {P}ineau, {P}. and {M}onbet, {V}. and {B}oudjema, {K}. and {T}axa, {L}. and {C}asavilca-{Z}ambrano, {S}. and {R}opert, {M}. and {T}urlin, {B}. and {L}oreal, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e have previously described a form of hepatocellular carcinoma ({HCC}) in non-cirrhotic liver ({HCC}-{NC}) developed by {P}eruvian patients. {W}e analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting {HCC}-{NC}. {C}linical, histopathological data, and {HCC} and non-tumoral liver ({NTL}) samples of 38 {P}eruvian and 38 {F}rench {HCC}-{NC} patients, were studied. {T}welve metals were quantified using {ICP}/{MS}: {M}n, {F}e, {C}u, {C}o, {Z}n, {A}s, {S}e, {R}b, {M}o, {C}d, {P}b, and {S}n. {A}ssociations between metals and survival were assessed. {O}ur data showed significant differences between cohorts. {M}ean ages were 40.6 +/- 20, 67.5 +/- 9 years old for {P}eruvians and {F}rench, respectively. {F}ifty percent of the {P}eruvian patients were positive for the {HB}s{A}g, versus 3% in {F}rench patients. {M}n, {C}u, {Z}n, {A}s, {S}e, {R}b, {M}o, {C}d, {S}n metal concentrations were higher in {NTL} of {P}eruvians. {I}mportantly, metal concentrations were lower in {HCC} areas compared to {NTL} tissues in both cohorts, except for {C}u for which mean concentration was higher in {HCC} (p<0.05). {S}e concentration in {HCC} was associated with extended survival only in {P}eruvians. {O}ur data, obtained in {P}eruvian and {F}rench {HCC}-{NC} cohorts, highlights similarity in the metallomic profile of {HCC} compared to {NTL} during the hepatic tumorigenesis in these specific groups of patients.},
  keywords = {{PEROU} ; {FRANCE}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {11},
  numero = {1},
  pages = {14195 [10 p.]},
  ISSN = {2045-2322},
  year = {2021},
  DOI = {10.1038/s41598-021-93369-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082679},
}