@article{fdi:010082633,
  title = {{E}pilepsy in the {S}anaga-{M}bam valley, an onchocerciasis-endemic region in {C}ameroon : electroclinical and neuropsychological findings},
  author = {{M}orin, {A}. and {G}uillaume, {M}. and {N}garka, {L}. and {T}atah, {G}. {Y}. and {F}odjo, {J}. {N}. {S}. and {W}yart, {G}. and {N}okam, {G}. and {T}choumi, {T}. and {N}kinin, {M}. {B}. and {N}jamnshi, {W}. {Y}. and {C}hokote, {E}. {S}. and {B}oussinesq, {M}ichel and {C}olebunders, {R}. and {C}hesnais, {C}{\'e}dric and {G}argala, {G}. and {P}arain, {D}. and {N}jamnshi, {A}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective {E}pilepsy is highly prevalent in onchocerciasis-endemic {A}frican regions. {V}arious types of epilepsy have been described in such regions based essentially on clinical characteristics. {M}ethods {W}e conducted a clinical, neurophysiological and neuropsychological study of epilepsy in the onchocerciasis-endemic region of {N}tui, {S}anaga-{M}bam area, {C}ameroon. {R}esults {O}ne hundred and eighty-seven persons with presumed epilepsy were recruited in an epilepsy clinic in {N}tui. {E}pilepsy was clinically confirmed in 144 (79%) subjects, 69 (46.0%) of them met the onchocerciasis-associated epilepsy ({OAE}) criteria, and 51 of 106 tested (48.1%) presented {O}v16 antibodies. {E}lectroencephalograms ({EEG}) were recorded in 91 participants, of which 36 (33%) were considered abnormal and 27 of 36 (75%) revealed bifrontotemporal spike and slow waves. {C}oncerning the neuropsychological evaluation, 29% showed severe global cognitive impairment, 28% severe episodic memory impairment, and 66% severe frontal cognitive impairment. {H}alf of the persons with epilepsy ({PWE}) suffered from a mental disorder. {S}ignificance {I}n {PWE} in the {S}anaga-{M}bam area in {C}ameroon, we observed {EEG} patterns similar to those described among persons with {OAE}, including nodding syndrome in other onchocerciasis-endemic areas. {M}ost {PWE} presented with severe cognitive impairment. {W}e hypothesize that onchocerciasis may induce neurocognitive disorders and epilepsy via a mechanism that involves mainly the frontal and temporal regions of the brain.},
  keywords = {onchocerciasis ; epilepsy ; neuropsychology ; electrophysiology ; nodding ; syndrome ; {C}ameroon ; {CAMEROUN} ; {SANAGA} {MBAM} {VALLEE}},
  booktitle = {},
  journal = {{E}pilepsia {O}pen},
  volume = {6},
  numero = {3},
  pages = {513--527},
  year = {2022},
  DOI = {10.1002/epi4.12510},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082633},
}