Garcia-Ruiz H. auteur aut IRD Szurek Boris auteur aut IRD Van den Ackerveken G. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Alternatives to protect crops against diseases are desperately needed to secure world food production and make agriculture more sustainable. Genetic resistance to pathogens utilized so far is mostly based on single dominant resistance genes that mediate specific recognition of invaders and that is often rapidly broken by pathogen variants. Perturbation of plant susceptibility (S) genes offers an alternative providing plants with recessive resistance that is proposed to be more durable. S genes enable the establishment of plant disease, and their inactivation provides opportunities for resistance breeding of crops. However, loss of S gene function can have pleiotropic effects. Developments in genome editing technology promise to provide powerful methods to precisely interfere with crop S gene functions and reduce tradeoffs. specialized 076 020 70 187-195 2021 0958-1669 https://www.documentation.ird.fr/hor/fdi:010082610 10.1016/j.copbio.2021.05.005 0958-1669 [F B010082610] https://www.documentation.ird.fr/hor/fdi:010082610 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-09/010082610.pdf IRD - Base Horizon / Pleins textes 2021-09-17 2025-02-24 fdi:010082610 fre