@article{fdi:010082408, title = {{T}he 5{P} program, personalized and participatory primary prevention pathway : rational and design of a clinical trial in general practice}, author = {{L}egrand, {F}. and {E}ychene, {J}.{M}. and {A}udiffren, {J}. and {K}lein, {A}. and {L}abourdette, {C}. and {N}icola{\¨ie}, {A}. and {S}andron, {F}r{\'e}d{\'e}ric and {V}idal, {P}.{P}.}, editor = {}, language = {{ENG}}, abstract = {{T}he aging of the population is leading to an increase in the number of people with loss of autonomy, placing a strain on the health care system. {I}ts prevention at early stages such as the frailty stage would allow an improvement in the quality of life of seniors while limiting health care expenses . {T}he "{A}tout {A}ge" prevention program set up by the health public authorities of {R}eunion {I}sland for retired people and the new frailty assessment tools based on mathematical machine learning algorithms could improve the ambulatory care of senior citizens . {A}t present, referral care remains hospital with comprehensive geriatric assessment and there is a lack of evidence of the effectiveness of a prevention pathway for loss of autonomy in primary care. {F}or these reasons, the 5{P} program "{P}ersonalized and {P}articipative {P}rimary {P}revention {P}athway" has been started in order to obtain scientific evidence. {I}n this article, we present the objectives, design and first results, used in the 5{P} program up to the implementation of a clinical trial in general practice. {T}he program is articulated in 3 phases. {A} first phase to evaluate the acceptability of innovative screening tools for frailty. {A} second pilot phase evaluates the feasibility of a large -scale ambulatory clinical trial in general practice . {T}he last phase described in this article, is a multi site, pseudo - randomized, controlled clinical trial measuring the impact of the "{A}tout {A}ge" work shop son the physical performance and the quality of life of seniors compared with their usual ambulatory follow-up .}, keywords = {{REUNION}}, booktitle = {}, journal = {{C}ontemporary {C}linical {T}rials {C}ommunications}, volume = {22}, numero = {}, pages = {100786 [6 ]}, ISSN = {2451-8654}, year = {2021}, DOI = {10.1016/j.conctc.2021.100786}, URL = {https://www.documentation.ird.fr/hor/fdi:010082408}, }