@article{fdi:010082184,
  title = {{A} strong effect of individual compliance with mass drug administration for lymphatic filariasis on sustained clearance of soil-transmitted helminth infections},
  author = {{C}ampillo, {J}. {T}. and {A}waca-{U}von, {N}. {P}. and {T}ambwe, {J}. {P}. and {K}uyangisa-{S}imuna, {G}. and {V}laminck, {J}. and {W}eil, {G}. {J}. and {B}oussinesq, {M}ichel and {C}hesnais, {C}{\'e}dric and {P}ion, {S}{\'e}bastien},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he impact of semiannual mass drug administration ({MDA}) with albendazole ({ALB}; 400 mg) alone on lymphatic filariasis ({LF}) and soil-transmitted helminth ({STH}) infections was assessed during two trials conducted from 2012 to 2018 in the {R}epublic of {C}ongo and the {D}emocratic {R}epublic of {C}ongo. {T}he collected data were analyzed to evaluate the effect of compliance with {ALB} treatment on {STH} infections. {M}ethods: {STH} infections were diagnosed with duplicate {K}ato-{K}atz thick smears and the results are reported as eggs per gram of stool. {A}ll subjects with at least two {STH} infection assessments were included in the analyses. {W}e used parametric survival models to assess the influence of compliance with {ALB} treatment on the probability of (i) achieving sustained clearance of an {STH} infection, and (ii) acquiring an {STH} infection during the follow-up. {R}esults: {O}ut of 2658 subjects included in the trials, data on 202 participants (701 person-years; {PY}) with hookworm infection, 211 (651 {PY}) with {A}scaris lumbricoides infection and 270 (1013 {PY}) with {T}richuris trichiura infection were available to calculate the probability of achieving sustained clearance of infection. {T}he effect of {ALB} was dose related for all three {STH}. {F}or hookworm, the time required for sustained clearance was longer (4.3 years, {P} < 0.001) for participants who took zero doses per year and shorter (3.4 years, {P} = 0.112) for participants who took two doses per year compared to those who took one dose per year (3.7 years). {F}or {A}scaris, the time required to obtain sustained clearance followed the same pattern: 6.1 years ({P} < 0.001) and 3.2 years ({P} = 0.004) vs 3.6 years for, zero, two and one dose per year, respectively. {F}or {T}richuris, less time was required for sustained clearance (4.2 years, {P} < 0.001) for fully compliant participants, i.e. those who took two doses per year, than for those who only took one dose per year (5.0 years). {ALB} was more effective in achieving sustained clearance of {STH} infection in subjects with light baseline infection intensities compared to those with higher egg counts. {C}onclusion: {O}ur results illustrate the importance of {MDA} compliance at the level of the individual with respect to the {STH} benefit provided by semiannual {ALB} {MDA}, which is used for the elimination of {LF} in {C}entral {A}frica.},
  keywords = {{S}oil-transmitted helminths ; {A}lbendazole ; {P}arametric survival analysis ; {T}reatment adherence ; {M}ass drug administration ; {CONGO}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {14},
  numero = {1},
  pages = {310 [10 ]},
  ISSN = {1756-3305},
  year = {2021},
  DOI = {10.1186/s13071-021-04814-2},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082184},
}