@article{fdi:010082127,
  title = {{T}hiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life},
  author = {{M}easelle, {J}. {R}. and {B}aldwin, {D}. {A}. and {G}allant, {J}. and {C}han, {K}. and {G}reen, {T}. {J}. and {W}ieringa, {F}ranck and {B}orath, {M}. and {P}rak, {S}. and {H}ampel, {D}. and {S}hahab-{F}erdows, {S}. and {A}llen, {L}. {H}. and {K}roeun, {H}. and {W}hitfield, {K}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}omen reliant on mostly rice-based diets can have inadequate thiamine intake, placing breastfed infants at risk of thiamine deficiency and, in turn, physical and cognitive impairments. {W}e investigated the impact of maternal thiamine supplementation doses on infants' cognitive, motor, and language development across the first year. {I}n this double-blind, four-parallel-arm, randomized controlled trial, healthy mothers of exclusively breastfed newborn infants were recruited in {K}ampong {T}hom, {C}ambodia. {A}t 2 weeks postnatal, women (n = 335) were randomized to one of four treatment groups to consume one capsule/day with varying amounts of thiamine for 22 weeks: 0, 1.2, 2.4, and 10 mg. {A}t 2, 12, 24, and 52 weeks of age, infants were assessed with the {M}ullen {S}cales of {E}arly {L}earning ({MSEL}) and the {C}aregiver {R}eported {E}arly {D}evelopment {I}nstrument ({CREDI}). {M}ultiple regression and mixed effects modeling suggest that by 6 months of age, the highest maternal thiamine dose (10 mg/day) held significant benefits for infants' language development, but generally not for motor or visual reception development. {D}espite having achieved standardized scores on the {MSEL} that approximated {U}.{S}. norms by 6 months, infants showed a significant drop relative to these norms in both language domains following trial completion, indicating that nutritional interventions beyond 6 months may be necessary.},
  keywords = {thiamine (vitamin {B}-1) ; supplementation ; {C}ambodia ; infancy ; cognitive ; development ; {CAMBODGE}},
  booktitle = {},
  journal = {{A}nnals of the {N}ew {Y}ork {A}cademy of {S}ciences},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[17 p.]},
  ISSN = {0077-8923},
  year = {2021},
  DOI = {10.1111/nyas.14610},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082127},
}