%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Mayxay, M.
%A Douangdala, P.
%A Vilayhong, C.
%A Phommasone, K.
%A Chansamouth, V.
%A Vongsouvath, M.
%A Rattanavong, S.
%A Chang, K.
%A Sengvilaipaseuth, O.
%A Chanthongthip, A.
%A Thongpaseuth, S.
%A Newton, P. N.
%A Dubot Pérès, Audrey
%T Outcome of Japanese Encephalitis Virus (JEV) Infection in pediatric and adult patients at Mahosot Hospital, Vientiane, Lao PDR
%D 2021
%L fdi:010082046
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K LAOS ; VIENTIANE
%M ISI:000651201600035
%N 2
%P 567-575
%R 10.4269/ajtmh.20-0581
%U https://www.documentation.ird.fr/hor/fdi:010082046
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-07/010082046.pdf
%V 104
%W Horizon (IRD)
%X Although Japanese encephalitis virus (JEV) infection is an important cause of acute febrile illness in Lao PDR (Laos), patient outcome has not been evaluated. We prospectively followed up 123 JEV-infected patients (70 children < 15 years and 53 adults 3 15 years) admitted at Mahosot Hospital, Vientiane, from 2003 to 2013. Japanese encephalitis virus infection was diagnosed by the detection of anti-JEV IgM in cerebrospinal fluid and/or IgM seroconversion. Neurological sequelae were assessed using the Liverpool Outcome Score (LOS), total (maximum score = 75), and final (maximum score = 5). The median (interquartile range [IQR]) age of the patients was 12.0 (7.5-18.8) years, and 57% were male. The median (IQR) duration of patients' follow-up was 4.5 (3.2-7.3) years. Of all patients, 10/123 (8.1%) died during hospitalization, and 13/123 (10.6%) died at home after discharge, giving a mortality of 18.7% (23/123) (33 [26.8%] patients were lost to follow-up). The frequency of neurological sequelae at the last follow-up was 61.2% (48.4% in adults and 69.4% in children, P = 0.135). The proportion of patients with severe and moderate functional impairment at the last follow-up was significantly higher in children (25%) than in adults (6.5%), P = 0.042. Half of the patients who were still alive at the last follow-up (67) and for whom LOS data were available (22) had improvements in their total and final LOS between discharge and the last follow-up. The total and final LOS at discharge were not significantly different between children and adults, but total LOS at the last follow-up was significantly higher in adults than in children (median [IQR]: 74.5 [73-75] versus 73.0 [73-75], P = 0.019).
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