@article{fdi:010082046,
  title = {{O}utcome of {J}apanese {E}ncephalitis {V}irus ({JEV}) {I}nfection in pediatric and adult patients at {M}ahosot {H}ospital, {V}ientiane, {L}ao {PDR}},
  author = {{M}ayxay, {M}. and {D}ouangdala, {P}. and {V}ilayhong, {C}. and {P}hommasone, {K}. and {C}hansamouth, {V}. and {V}ongsouvath, {M}. and {R}attanavong, {S}. and {C}hang, {K}. and {S}engvilaipaseuth, {O}. and {C}hanthongthip, {A}. and {T}hongpaseuth, {S}. and {N}ewton, {P}. {N}. and {D}ubot {P}{\'e}r{\`e}s, {A}udrey},
  editor = {},
  language = {{ENG}},
  abstract = {{A}lthough {J}apanese encephalitis virus ({JEV}) infection is an important cause of acute febrile illness in {L}ao {PDR} ({L}aos), patient outcome has not been evaluated. {W}e prospectively followed up 123 {JEV}-infected patients (70 children < 15 years and 53 adults 3 15 years) admitted at {M}ahosot {H}ospital, {V}ientiane, from 2003 to 2013. {J}apanese encephalitis virus infection was diagnosed by the detection of anti-{JEV} {I}g{M} in cerebrospinal fluid and/or {I}g{M} seroconversion. {N}eurological sequelae were assessed using the {L}iverpool {O}utcome {S}core ({LOS}), total (maximum score = 75), and final (maximum score = 5). {T}he median (interquartile range [{IQR}]) age of the patients was 12.0 (7.5-18.8) years, and 57% were male. {T}he median ({IQR}) duration of patients' follow-up was 4.5 (3.2-7.3) years. {O}f all patients, 10/123 (8.1%) died during hospitalization, and 13/123 (10.6%) died at home after discharge, giving a mortality of 18.7% (23/123) (33 [26.8%] patients were lost to follow-up). {T}he frequency of neurological sequelae at the last follow-up was 61.2% (48.4% in adults and 69.4% in children, {P} = 0.135). {T}he proportion of patients with severe and moderate functional impairment at the last follow-up was significantly higher in children (25%) than in adults (6.5%), {P} = 0.042. {H}alf of the patients who were still alive at the last follow-up (67) and for whom {LOS} data were available (22) had improvements in their total and final {LOS} between discharge and the last follow-up. {T}he total and final {LOS} at discharge were not significantly different between children and adults, but total {LOS} at the last follow-up was significantly higher in adults than in children (median [{IQR}]: 74.5 [73-75] versus 73.0 [73-75], {P} = 0.019).},
  keywords = {{LAOS} ; {VIENTIANE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {104},
  numero = {2},
  pages = {567--575},
  ISSN = {0002-9637},
  year = {2021},
  DOI = {10.4269/ajtmh.20-0581},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082046},
}