%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Parent, J. S.
%A Cahn, J.
%A Herridge, R. P.
%A Grimanelli, Daniel
%A Martienssen, R. A.
%T Small RNAs guide histone methylation in Arabidopsis embryos
%D 2021
%L fdi:010082042
%G ENG
%J Genes and Development
%@ 0890-9369
%K epigenetic reprogramming ; small RNA molecules ; DNA methylation ; plant embryogenesis ; histone methylation
%M ISI:000656852100005
%N 11-12
%P 841-846
%R 10.1101/gad.343871.120
%U https://www.documentation.ird.fr/hor/fdi:010082042
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-07/010082042.pdf
%V 35
%W Horizon (IRD)
%X Epigenetic reprogramming occurs during gametogenesis as well as during embryogenesis to reset the genome for early development. In flowering plants, many heterochromatic marks are maintained in sperm, but asymmetric DNA methylation is mostly lost. Asymmetric DNA methylation is dependent on small RNA but the re-establishment of silencing in embryo is not well understood. Here we demonstrate that small RNAs direct the histone H3 lysine 9 dimethylation during Arabidopsis thaliana embryonic development, together with asymmetric DNA methylation. This de novo silencing mechanism depends on the catalytic domain of SUVH9, a Su(Var)3-9 homolog thought to be catalytically inactive.
%$ 076 ; 020