Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana : transdisciplinarity does matter to tackle new emerging threats de Thoisy B. auteur aut IRD Duron O. auteur aut IRD Epelboin L. auteur aut IRD Musset L. auteur aut IRD Quénel P. auteur aut IRD Roche Benjamin auteur aut IRD Binetruy F. auteur aut IRD Briolant S. auteur aut IRD Carvalho L. auteur aut IRD Chavy A. auteur aut IRD Couppié P. auteur aut IRD Demar M. auteur aut IRD Douine M. auteur aut IRD Dusfour I. auteur aut IRD Epelboin Y. auteur aut IRD Flamand C. auteur aut IRD Franc A. auteur aut IRD Ginouvès M. auteur aut IRD Gourbière S. auteur aut IRD Houel E. auteur aut IRD Kocher A. auteur aut IRD Lavergne A. auteur aut IRD Le Turnier P. auteur aut IRD Mathieu L. auteur aut IRD Murienne J. auteur aut IRD Nacher M. auteur aut IRD Pelleau S. auteur aut IRD Prévot G. auteur aut IRD Rousset D. auteur aut IRD Roux Emmanuel auteur aut IRD Schaub R. auteur aut IRD Talaga S. auteur aut IRD Thill P. auteur aut IRD Tirera S. auteur aut IRD Guégan Jean-François auteur aut IRD text journalArticle eng text/pdf born digital access French Guiana is a European ultraperipheric region located on the northern Atlantic coast of South America. It constitutes an important forested region for biological conservation in the Neotropics. Although very sparsely populated, with its inhabitants mainly concentrated on the Atlantic coastal strip and along the two main rivers, it is marked by the presence and development of old and new epidemic disease outbreaks, both research and health priorities. In this review paper, we synthetize 15 years of multidisciplinary and integrative research at the interface between wildlife, ecosystem modification, human activities and sociodemographic development, and human health. This study reveals a complex epidemiological landscape marked by important transitional changes, facilitated by increased interconnections between wildlife, land-use change and human occupation and activity, human and trade transportation, demography with substantial immigration, and identified vector and parasite pharmacological resistance. Among other French Guianese characteristics, we demonstrate herein the existence of more complex multi-host disease life cycles than previously described for several disease systems in Central and South America, which clearly indicates that today the greater promiscuity between wildlife and humans due to demographic and economic pressures may offer novel settings for microbes and their hosts to circulate and spread. French Guiana is a microcosm that crystallizes all the current global environmental, demographic and socioeconomic change conditions, which may favor the development of ancient and future infectious diseases. specialized GUYANE FRANCAISE AMAZONIE 050 082 106 108 Infection, Genetics and Evolution 93 104916 [18 ] 2021 1567-1348 https://www.documentation.ird.fr/hor/fdi:010082019 10.1016/j.meegid.2021.104916 1567-1348 [F B010082019] https://www.documentation.ird.fr/hor/fdi:010082019 https://www.documentation.ird.fr/intranet/publi/2021-06/010082019.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2021-06-24 2025-02-24 fdi:010082019 fre