%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Silva Zanetti, L.da
%A Cagnoni Balestra, A.
%A Amorim, J.
%A Ramalho, F.S.
%A Souza Wanderley, C.W.de
%A Mesquita Luiz, J.P.
%A Delprete, Piero
%A Soares Pereira, A.M.
%A Carvalho Borges, M.de
%A Carmona, F.
%T Uncaria guianensis (Aubl.) J.F. Gmel. extracts reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma
%D 2020
%L fdi:010081728
%G ENG
%J Journal of Pharmacognosy and Phytotherapy
%@ 2141-2502
%K BRESIL ; SAO PAULO
%N 4
%P D1AB63A64968 [81-93]
%R 10.5897/JPP2020.0578
%U https://www.documentation.ird.fr/hor/fdi:010081728
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-08/010081728.pdf
%V 12
%W Horizon (IRD)
%X Uncaria guianensis (Aubl.) J. F. Gmel. ("cat's claw", Rubiaceae) is a plant with potential to treat asthma because  of  its anti-inflammatory  and  antioxidant  activities. The aim of  this  study  was  to evaluate  the effects  of  two extracts of U.  guianensisin  an  animal  model of allergic asthma. Balb/c  mice  were sensitized  twice  with  ovalbumin  intraperitoneally  one  week  apart,  then challenged  with  intranasal ovalbumin for three days. Animals weretreated with aqueous or hydroethanolic extracts (100 mg/kg) for three  days, simultaneously  with ovalbumin challenges.  Control  mice  received  saline  solution  on  the same days. In vivo bronchial hyper responsiveness, airway and lung inflammation, IgE levels, and total antioxidant  capacitywere  measured. Treatment  with the  hydroethanolic  extract significantly  reduced total cell and eosinophil counts in bronchoalveolar lavage, and in vivobronchial hyper responsiveness. Moreover, U.  guianensis hydroethanolic  extract  significantly reduced interleukin  13  levels  in  lung homogenate. Total  antioxidant  capacity  and IgE  serum  levels  were  not  affected with the extract administration. Of note, treatment with the aqueous extract did not elicit significant effectson asthma-like characteristics. Only the  hydroethanolic  extractof U.  guianensis reduced  lung  inflammation  and bronchial hyper responsiveness in asthmatic mice
%$ 076 ; 050 ; 080