@article{fdi:010081728,
  title = {{U}ncaria guianensis ({A}ubl.) {J}.{F}. {G}mel. extracts reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma},
  author = {{S}ilva {Z}anetti, {L}.da and {C}agnoni {B}alestra, {A}. and {A}morim, {J}. and {R}amalho, {F}.{S}. and {S}ouza {W}anderley, {C}.{W}.de and {M}esquita {L}uiz, {J}.{P}. and {D}elprete, {P}iero and {S}oares {P}ereira, {A}.{M}. and {C}arvalho {B}orges, {M}.de and {C}armona, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{U}ncaria guianensis ({A}ubl.) {J}. {F}. {G}mel. ("cat's claw", {R}ubiaceae) is a plant with potential to treat asthma because  of  its anti-inflammatory  and  antioxidant  activities. {T}he aim of  this  study  was  to evaluate  the effects  of  two extracts of {U}.  guianensisin  an  animal  model of allergic asthma. {B}alb/c  mice  were sensitized  twice  with  ovalbumin  intraperitoneally  one  week  apart,  then challenged  with  intranasal ovalbumin for three days. {A}nimals weretreated with aqueous or hydroethanolic extracts (100 mg/kg) for three  days, simultaneously  with ovalbumin challenges.  {C}ontrol  mice  received  saline  solution  on  the same days. {I}n vivo bronchial hyper responsiveness, airway and lung inflammation, {I}g{E} levels, and total antioxidant  capacitywere  measured. {T}reatment  with the  hydroethanolic  extract significantly  reduced total cell and eosinophil counts in bronchoalveolar lavage, and in vivobronchial hyper responsiveness. {M}oreover, {U}.  guianensis hydroethanolic  extract  significantly reduced interleukin  13  levels  in  lung homogenate. {T}otal  antioxidant  capacity  and {I}g{E}  serum  levels  were  not  affected with the extract administration. {O}f note, treatment with the aqueous extract did not elicit significant effectson asthma-like characteristics. {O}nly the  hydroethanolic  extractof {U}.  guianensis reduced  lung  inflammation  and bronchial hyper responsiveness in asthmatic mice},
  keywords = {{BRESIL} ; {SAO} {PAULO}},
  booktitle = {},
  journal = {{J}ournal of {P}harmacognosy and {P}hytotherapy},
  volume = {12},
  numero = {4},
  pages = {{D}1{AB}63{A}64968 [81--93]},
  ISSN = {2141-2502},
  year = {2020},
  DOI = {10.5897/{JPP}2020.0578},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081728},
}