@article{fdi:010081705,
  title = {{V}alidation of the {D}:{A}:{D} chronic kidney disease risk score in people living with {HIV} : the {I}e{DEA} {W}est {A}frica {C}ohort {C}ollaboration},
  author = {{P}oda, {A}. and {K}abore, {N}.{F}. and {M}alateste, {K}. and {R}ekeneire, {N}. de. and {S}emde, {A}. and {B}ikinga, {Y}. and {P}atassi, {A}. and {C}henal, {H}. and {M}essou, {E}. and {D}abis, {F}. and {E}kouevi, {D}.{K}. and {J}aquet, {A}. and {C}ournil, {A}mandine},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {A} risk score for long-term prediction of chronic kidney disease ({CKD}) in people living with {HIV} ({PLHIV}) has been developed using data from the {D}:{A}:{D} cohort. {W}e assessed the performance of the {D}:{A}:{D} risk score in a cohort of {PLHIV} in {W}est {A}frica. {M}ethods : {D}ata from {PLHIV} starting antiretroviral treatment in four clinics in {B}urkina {F}aso, {C}{\^o}te d'{I}voire and {T}ogo participating in the {I}e{DEA} {W}est {A}frica collaboration were analysed. {CKD} was defined as two consecutive estimated glomerular filtration rates (e{GFR}s) of ≤ 60 m{L}/min/1.73 m2. {T}he {D}:{A}:{D} score (short version) was calculated using age, gender, nadir {CD}4 and baseline e{GFR} and was categorized into low, medium, and high-risk groups. {R}esults : {I}n 14 930 participants (70% female, median age = 38 years; median nadir {CD}4 count = 183 cells/µ{L}) followed for a median duration of 5.7 years, 660 (4.4%) progressed to {CKD}, with an incidence [95% confidence interval ({CI})] of 7.8 (7.2-8.4) per 1000 person-years ({PY}). {CKD} incidence rates were 2.4 (2.0-2.8), 8.1 (6.8-9.6) and, 30.9 (28.0-34.1) per 1000 {PY} in the low-, medium- and high-risk groups, respectively. {I}n the high-risk group, 14.7% (95% {CI}: 13.3; 16.3) had progressed to {CKD} at 5 years. {D}iscrimination was good [{C}-statistics = 0.81 (0.79-0.83)]. {I}n all, 79.4% of people who progressed to {CKD} were classified in the medium- to high-risk group at baseline (sensitivity) and 66.5% of people classified in the low risk group at baseline did not progress to {CKD} (specificity). {C}onclusions : {T}hese findings confirm the validity of the {D}:{A}:{D} score in identifying individuals at risk of developing {CKD} who could benefit from enhanced kidney monitoring in {W}est {A}frican {HIV} clinics},
  keywords = {{BENIN} ; {BURKINA} {FASO} ; {COTE} {D}'{IVOIRE} ; {TOGO} ; {SENEGAL}},
  booktitle = {},
  journal = {{HIV} {M}edicine},
  volume = {22},
  numero = {2},
  pages = {113--121},
  ISSN = {1464-2662},
  year = {2021},
  DOI = {10.1111/hiv.12982},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081705},
}