Chawech R. auteur aut IRD Jarraya R. auteur aut IRD Girardi C. auteur aut IRD Vansteelandt M. auteur aut IRD Marti G. auteur aut IRD Nasri I. auteur aut IRD Racaud-Sultan C. auteur aut IRD Fabre Nicolas auteur aut IRD text journalArticle eng text/pdf reformatted digital access Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines. specialized Citrullus colocynthis cucurbitacins cytotoxicity 076 020 20 10 18001-18015 2015 1420-3049 https://www.documentation.ird.fr/hor/fdi:010081648 10.3390/molecules201018001 1420-3049 [F B010081648] https://www.documentation.ird.fr/hor/fdi:010081648 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers21-03/010081648.pdf IRD - Base Horizon / Pleins textes 2016-01-14 2021-04-01 fdi:010081648 fre