@article{fdi:010081583,
  title = {{R}ole of heat-labile serum factor or host complement in the inhibition of {P}lasmodium falciparum sporogonic stages in {A}nopheles stephensi by gametocyte carriers' serological factors},
  author = {{G}ouagna, {L}ouis-{C}l{\'e}ment and {V}an der {K}olk, {M}. and {R}oeffen, {W}. and {V}erhave, {J}. {P}. and {E}ling, {W}. and {S}auerwein, {R}. and {B}oudin, {C}hristian},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study investigated the significance of serum complement on transmission-reducing activity ({TRA}) of field sera from 24 infected {P}lasmodium falciparum gametocyte carriers (from {C}ameroon) against cultured {NF}54 {P}. falciparum. {L}aboratory-reared {A}nopheles stephensi were given infectious blood meals prepared either with sera from naive {D}utch donor ({AB} type) or pair-matched field serum samples, both with and without active complement. {TRA} of serum factors and host complement on mosquito infection rate and oocyst intensity were divided into the various components involved in the early stages of sporogony. {T}he majority (>80%) of sera tested showed positive antibody titres to {P}fs230, the relevant complement-dependent target of transmission -reducing mechanisms. {R}egardless of the presence of active complement, bloodmeals with field sera exhibited significantly lower infection rates and oocyst intensity than the control group. {S}erological reactivity in {C}apture-{ELISA} against {P}fs230 was significantly correlated with the reduction of parasite infectivity. {C}ontrary to our expectation, the presence of active complement in the mosquito bloodmeal did not increase parasite losses and therefore the magnitude of transmission reduction by individual immune sera. {O}ur findings on {P}.falciparum are consistent with previous studies on animal hosts of {P}lasmodium, indicating that early {P}.falciparum sporogonic stages may be insensitive to the antibody-dependent pathways of complement in human serum.},
  keywords = {plasmodium falciparum ; gametocyte carriers ; complement ; {A}nopheles stephensi ; sporogony ; transmission reducing immunity},
  booktitle = {},
  journal = {{P}arasitology},
  volume = {134},
  numero = {10},
  pages = {1315--1327},
  ISSN = {0031-1820},
  year = {2007},
  DOI = {10.1017/{S}0031182007002685},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081583},
}