Bertin P. N. auteur aut IRD Heinrich-Salmeron A. auteur aut IRD Pelletier E. auteur aut IRD Goulhen-Chollet F. auteur aut IRD Arsene-Ploetze F. auteur aut IRD Gallien S. auteur aut IRD Lauga B. auteur aut IRD Casiot C. auteur aut IRD Calteau A. auteur aut IRD Vallenet D. auteur aut IRD Bonnefoy V. auteur aut IRD Bruneel Odile auteur aut IRD Chane-Woon-Ming B. auteur aut IRD Cleiss-Arnold J. auteur aut IRD Duran R. auteur aut IRD Elbaz-Poulichet F. auteur aut IRD Fonknechten N. auteur aut IRD Giloteaux L. auteur aut IRD Halter D. auteur aut IRD Koechler S. auteur aut IRD Marchal M. auteur aut IRD Mornico D. auteur aut IRD Schaeffer C. auteur aut IRD Smith A. A. T. auteur aut IRD Van Dorsselaer A. auteur aut IRD Weissenbach J. auteur aut IRD Medigue C. auteur aut IRD Le Paslier D. auteur aut IRD text journalArticle eng text/pdf reformatted digital access By their metabolic activities, microorganisms have a crucial role in the biogeochemical cycles of elements. The complete understanding of these processes requires, however, the deciphering of both the structure and the function, including synecologic interactions, of microbial communities. Using a metagenomic approach, we demonstrated here that an acid mine drainage highly contaminated with arsenic is dominated by seven bacterial strains whose genomes were reconstructed. Five of them represent yet uncultivated bacteria and include two strains belonging to a novel bacterial phylum present in some similar ecosystems, and which was named 'Candidatus Fodinabacter communificans.' Metaproteomic data unravelled several microbial capabilities expressed in situ, such as iron, sulfur and arsenic oxidation that are key mechanisms in biomineralization, or organic nutrient, amino acid and vitamin metabolism involved in synthrophic associations. A statistical analysis of genomic and proteomic data and reverse transcriptase-PCR experiments allowed us to build an integrated model of the metabolic interactions that may be of prime importance in the natural attenuation of such anthropized ecosystems. specialized microbial genomics extreme environment uncultured microorganism bacterial phylum synecology functional ecology 084 020 082 5 11 1735-1747 2011 1751-7362 https://www.documentation.ird.fr/hor/fdi:010081550 10.1038/ismej.2011.51 1751-7362 [F B010081550] https://www.documentation.ird.fr/hor/fdi:010081550 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers21-02/010081550.pdf IRD - Base Horizon / Pleins textes 2012-02-01 2021-03-11 fdi:010081550 fre