Tornyigah B. auteur aut IRD d'Almeida T. auteur aut IRD Escriou G. auteur aut IRD Viwami F. auteur aut IRD Fievet Nadine auteur aut IRD Luty Adrian auteur aut IRD Massougbodji A. auteur aut IRD Nielsen M. A. auteur aut IRD Deloron Philippe auteur aut IRD Tuikue Ndam Nicaise auteur aut IRD text journalArticle eng text/pdf reformatted digital access Sequestration of Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen in the placenta results in poor pregnancy outcomes, including low birth weight and maternal anemia. Antigen-specific antibody-mediated immunity is acquired during successive pregnancies. Thus, evaluating VAR2CSA-specific IgG profiles among pregnant women will increase knowledge on the immunological mechanisms associated with protection, and help in the development of VAR2CSA-based placental malaria vaccines. Using the PAMVAC candidate vaccine antigen, we assessed anti-VAR2CSA IgG subclass responses of a cohort of pregnant Beninese, and analyzed their relationships with pregnancy outcomes. Cytophilic IgG1 and IgG3 responses were the most frequent, with prevalences ranging from 28% (IgG3) up to 50% (IgG1). Elevated levels of VAR2CSA-specific total IgG and cytophilic IgG3 during pregnancy were consistently associated with higher birth weights, whilst high levels of IgG4 were associated with a reduced risk of placental infections. This suggests that protective anti-VAR2CSA IgG responses are coordinated between both cytophilic and non-cytophilic antibodies. specialized pregnancy malaria VAR2CSA IgG subclasses IgG3 IgG4 050 052 12 610305 [8 p.] 2021 1664-3224 https://www.documentation.ird.fr/hor/fdi:010081425 10.3389/fimmu.2021.610305 1664-3224 [F B010081425] https://www.documentation.ird.fr/hor/fdi:010081425 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-06/010081425.pdf IRD - Base Horizon / Pleins textes 2021-06-15 2025-02-24 fdi:010081425 fre