Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Frontiers in Immunology 610305 [8 p.] pregnancy malaria VAR2CSA IgG subclasses IgG3 IgG4 2021 fdi:010081425 ENG Frontiers in Immunology 1664-3224 ISI:000647107800001 10.3389/fimmu.2021.610305 https://www.documentation.ird.fr/hor/fdi:010081425 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-06/010081425.pdf 12 Horizon (IRD) Sequestration of Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen in the placenta results in poor pregnancy outcomes, including low birth weight and maternal anemia. Antigen-specific antibody-mediated immunity is acquired during successive pregnancies. Thus, evaluating VAR2CSA-specific IgG profiles among pregnant women will increase knowledge on the immunological mechanisms associated with protection, and help in the development of VAR2CSA-based placental malaria vaccines. Using the PAMVAC candidate vaccine antigen, we assessed anti-VAR2CSA IgG subclass responses of a cohort of pregnant Beninese, and analyzed their relationships with pregnancy outcomes. Cytophilic IgG1 and IgG3 responses were the most frequent, with prevalences ranging from 28% (IgG3) up to 50% (IgG1). Elevated levels of VAR2CSA-specific total IgG and cytophilic IgG3 during pregnancy were consistently associated with higher birth weights, whilst high levels of IgG4 were associated with a reduced risk of placental infections. This suggests that protective anti-VAR2CSA IgG responses are coordinated between both cytophilic and non-cytophilic antibodies. 050 ; 052 UR261 Bénin / Ghana