%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Tornyigah, B.
%A d'Almeida, T.
%A Escriou, G.
%A Viwami, F.
%A Fievet, Nadine
%A Luty, Adrian
%A Massougbodji, A.
%A Nielsen, M. A.
%A Deloron, Philippe
%A Tuikue Ndam, Nicaise
%T Plasmodium falciparum VAR2CSA-specific IgG subclass responses reflect protection against low birth weight and pregnancy-associated malaria
%D 2021
%L fdi:010081425
%G ENG
%J Frontiers in Immunology
%@ 1664-3224
%K pregnancy ; malaria ; VAR2CSA ; IgG subclasses ; IgG3 ; IgG4
%M ISI:000647107800001
%P 610305 [8 ]
%R 10.3389/fimmu.2021.610305
%U https://www.documentation.ird.fr/hor/fdi:010081425
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-06/010081425.pdf
%V 12
%W Horizon (IRD)
%X Sequestration of Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen in the placenta results in poor pregnancy outcomes, including low birth weight and maternal anemia. Antigen-specific antibody-mediated immunity is acquired during successive pregnancies. Thus, evaluating VAR2CSA-specific IgG profiles among pregnant women will increase knowledge on the immunological mechanisms associated with protection, and help in the development of VAR2CSA-based placental malaria vaccines. Using the PAMVAC candidate vaccine antigen, we assessed anti-VAR2CSA IgG subclass responses of a cohort of pregnant Beninese, and analyzed their relationships with pregnancy outcomes. Cytophilic IgG1 and IgG3 responses were the most frequent, with prevalences ranging from 28% (IgG3) up to 50% (IgG1). Elevated levels of VAR2CSA-specific total IgG and cytophilic IgG3 during pregnancy were consistently associated with higher birth weights, whilst high levels of IgG4 were associated with a reduced risk of placental infections. This suggests that protective anti-VAR2CSA IgG responses are coordinated between both cytophilic and non-cytophilic antibodies.
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