@article{fdi:010081425,
  title = {{P}lasmodium falciparum {VAR}2{CSA}-specific {I}g{G} subclass responses reflect protection against low birth weight and pregnancy-associated malaria},
  author = {{T}ornyigah, {B}. and d'{A}lmeida, {T}. and {E}scriou, {G}. and {V}iwami, {F}. and {F}ievet, {N}adine and {L}uty, {A}drian and {M}assougbodji, {A}. and {N}ielsen, {M}. {A}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{S}equestration of {P}lasmodium falciparum-infected erythrocytes expressing the {VAR}2{CSA} antigen in the placenta results in poor pregnancy outcomes, including low birth weight and maternal anemia. {A}ntigen-specific antibody-mediated immunity is acquired during successive pregnancies. {T}hus, evaluating {VAR}2{CSA}-specific {I}g{G} profiles among pregnant women will increase knowledge on the immunological mechanisms associated with protection, and help in the development of {VAR}2{CSA}-based placental malaria vaccines. {U}sing the {PAMVAC} candidate vaccine antigen, we assessed anti-{VAR}2{CSA} {I}g{G} subclass responses of a cohort of pregnant {B}eninese, and analyzed their relationships with pregnancy outcomes. {C}ytophilic {I}g{G}1 and {I}g{G}3 responses were the most frequent, with prevalences ranging from 28% ({I}g{G}3) up to 50% ({I}g{G}1). {E}levated levels of {VAR}2{CSA}-specific total {I}g{G} and cytophilic {I}g{G}3 during pregnancy were consistently associated with higher birth weights, whilst high levels of {I}g{G}4 were associated with a reduced risk of placental infections. {T}his suggests that protective anti-{VAR}2{CSA} {I}g{G} responses are coordinated between both cytophilic and non-cytophilic antibodies.},
  keywords = {pregnancy ; malaria ; {VAR}2{CSA} ; {I}g{G} subclasses ; {I}g{G}3 ; {I}g{G}4},
  booktitle = {},
  journal = {{F}rontiers in {I}mmunology},
  volume = {12},
  numero = {},
  pages = {610305 [8 p.]},
  ISSN = {1664-3224},
  year = {2021},
  DOI = {10.3389/fimmu.2021.610305},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081425},
}