@article{fdi:010081359,
  title = {{I}nversion breakpoints and the evolution of supergenes},
  author = {{V}illoutreix, {R}. and {A}yala, {D}iego and {J}oron, {M}. and {G}ompert, {Z}. and {F}eder, {J}. {L}. and {N}osil, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he coexistence of discrete morphs that differ in multiple traits is common within natural populations of many taxa. {S}uch morphs are often associated with chromosomal inversions, presumably because the recombination suppressing effects of inversions help maintain alternate adaptive combinations of alleles across the multiple loci affecting these traits. {H}owever, inversions can also harbour selected mutations at their breakpoints, leading to their rise in frequency in addition to (or independent from) their role in recombination suppression. {I}n this review, we first describe the different ways that breakpoints can create mutations. {W}e then critically examine the evidence for the breakpoint-mutation and recombination suppression hypotheses for explaining the existence of discrete morphs associated with chromosomal inversions. {W}e find that the evidence that inversions are favoured due to recombination suppression is often indirect. {T}he evidence that breakpoints harbour mutations that are adaptive is also largely indirect, with the characterization of inversion breakpoints at the sequence level being incomplete in most systems. {D}irect tests of the role of suppressed recombination and breakpoint mutations in inversion evolution are thus needed. {F}inally, we emphasize how the two hypotheses of recombination suppression and breakpoint mutation can act in conjunction, with implications for understanding the emergence of supergenes and their evolutionary dynamics. {W}e conclude by discussing how breakpoint characterization could improve our understanding of complex, discrete phenotypic forms in nature.},
  keywords = {chromosomal inversion ; genome evolution ; linkage ; mutation ; recombination},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[18 p.]},
  ISSN = {0962-1083},
  year = {2021},
  DOI = {10.1111/mec.15907},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081359},
}