%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Traore, D. F.
%A Sagna, A. B.
%A Assi, S. B.
%A Tchiekoi, B. N.
%A Adja, A. M.
%A Dagnogo, M.
%A Koffi, A. A.
%A Rogier, C.
%A Remoué, Franck
%T Operational evaluation of the effectiveness of long-lasting insecticidal nets on human-vector contact in an African urban malaria context
%D 2021
%L fdi:010081343
%G ENG
%J Open Forum Infectious Diseases
%@ 2328-8957
%K urban areas ; salivary biomarkers ; gSG6-P1 ; Anopheles ; LLIN use
%K COTE D'IVOIRE ; BOUAKE
%M ISI:000637323400022
%N 2
%P ofaa635 [7 ]
%R 10.1093/ofid/ofaa635
%U https://www.documentation.ird.fr/hor/fdi:010081343
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-06/010081343.pdf
%V 8
%W Horizon (IRD)
%X Background. Malaria is still a major public health concern in Cote d'Ivoire despite mass distribution of long-lasting insecticidal nets (LLINs) as a key preventive strategy. This study intended to evaluate the operational effectiveness of LLINs on the level of human-vector contact using 1 antibody-based biomarker of exposure to Anopheles in urban areas. Methods. This cross-sectional study collected socio-demographic data and use of LLINs from 9 neighborhoods in the city of Bouake (Cote d'Ivoire). Dry blood spots performed in children aged >6 months and adults were used to evaluate immunoglobulin G (IgG) responses to the Anopheles gSG6-P1 salivary peptide. Results. IgG response levels to the salivary peptide were significantly lower in individuals who declared having "always" (n=270) slept under an LLIN compared with those who had "often" (n=2087) and "never" (n=88) slept under an LLIN (P<.0001). IgG response levels to gSG6-P1 between those who declared having "always" and "not always" slept under an LLIN varied according to neighborhood, socio-professional category, and age group. Conclusions. The human IgG level to this gSG6-P1 salivary peptide could be a useful tool to evaluate the actual effectiveness of LLINs and help design behavioral change interventions that are crucial for sustaining universal coverage.
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