@article{fdi:010081307,
  title = {{S}ickle cell trait modulates the proteome and phosphoproteome of {P}lasmodium falciparum-infected erythrocytes},
  author = {{C}hauvet, {M}. and {C}hhuon, {C}. and {L}ipecka, {J}. and {D}echavanne, {S}. and {D}echavanne, {C}{\'e}lia and {L}ohezic, {M}. and {O}rtalli, {M}. and {P}ineau, {D}. and {R}ibeil, {J}. {A}. and {M}anceau, {S}. and {L}e {V}an {K}im, {C}. and {L}uty, {A}drian and {M}igot {N}abias, {F}lorence and {A}zouzi, {S}. and {G}uerrera, {I}. {C}. and {M}erckx, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he high prevalence of sickle cell disease in some human populations likely results from the protection afforded against severe {P}lasmodium falciparum malaria and death by heterozygous carriage of {H}b{S}. {P}. falciparum remodels the erythrocyte membrane and skeleton, displaying parasite proteins at the erythrocyte surface that interact with key human proteins in the {A}nkyrin {R} and 4.1{R} complexes. {O}xidative stress generated by {H}b{S}, as well as by parasite invasion, disrupts the kinase/phosphatase balance, potentially interfering with the molecular interactions between human and parasite proteins. {H}b{S} is known to be associated with abnormal membrane display of parasite antigens. {S}tudying the proteome and the phosphoproteome of red cell membrane extracts from {P}. falciparum infected and non-infected erythrocytes, we show here that {H}b{S} heterozygous carriage, combined with infection, modulates the phosphorylation of erythrocyte membrane transporters and skeletal proteins as well as of parasite proteins. {O}ur results highlight modifications of {S}er-/{T}hr- and/or {T}yr- phosphorylation in key human proteins, such as ankyrin, beta-adducin, beta-spectrin and {B}and 3, and key parasite proteins, such as {RESA} or {MESA}. {A}ltered phosphorylation patterns could disturb the interactions within membrane protein complexes, affect nutrient uptake and the infected erythrocyte cytoadherence phenomenon, thus lessening the severity of malaria symptoms.},
  keywords = {{P}lasmodium falciparum ; hemoglobin {S} ; erythrocyte ; membrane ; phosphorylation ; proteomics},
  booktitle = {},
  journal = {{F}rontiers in {C}ellular and {I}nfection {M}icrobiology},
  volume = {11},
  numero = {},
  pages = {637604 [15 p.]},
  ISSN = {2235-2988},
  year = {2021},
  DOI = {10.3389/fcimb.2021.637604},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081307},
}