@article{fdi:010081255,
  title = {{C}linical evidence of the role of {M}ethanobrevibacter smithii in severe acute malnutrition},
  author = {{C}amara, {A}. and {K}onate, {S}. and {T}idjani {A}lou, {M}aryam and {K}odio, {A}. and {T}ogo, {A}. {H}. and {C}ortaredona, {S}{\'e}bastien and {H}enrissat, {B}. and {T}hera, {M}. {A}. and {D}oumbo, {O}. {K}. and {R}aoult, {D}. and {M}illion, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{G}ut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition ({SAM}) and particularly, the absence of {M}ethanobrevibacter smithii, a key player in energy harvest. {N}evertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. {I}n order to assess that, we performed a case-control study in {M}ali using a propensity score weighting approach. {T}he presence of {M}. smithii was tested using quantitative {PCR} on faeces collected from {SAM} children at inclusion and at discharge when possible or at day 15 for controls. {M}. smithii was highly significantly associated with the absence of {SAM}, detected in 40.9% controls but only in 4.2% cases (p<0.0001). {T}he predictive positive value for detection of {M}. smithii gradually increased with age in controls while decreasing in cases. {A}mong children providing two samples with a negative first sample, no {SAM} children became positive, while this proportion was 2/4 in controls (p=0.0015). {T}his data suggests that gut dysbiosis in {SAM} is not an immaturity but rather features a loss of {M}. smithii. {T}he addition of {M}. smithii as a probiotic may thus represent an important addition to therapeutic approaches to restore gut symbiosis.},
  keywords = {{MALI}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {11},
  numero = {1},
  pages = {5426 [11 p.]},
  ISSN = {2045-2322},
  year = {2021},
  DOI = {10.1038/s41598-021-84641-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081255},
}