Moriou C. auteur aut IRD Lacroix D. auteur aut IRD Petek Sylvain auteur aut IRD El-Demerdash A. auteur aut IRD Trepos R. auteur aut IRD Leu T. M. auteur aut IRD Florean C. auteur aut IRD Diederich M. auteur aut IRD Hellio C. auteur aut IRD Debitus Cécile auteur aut IRD Al-Mourabit A. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Chemical investigation of the South-Pacific marine sponge Suberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1-8 (2-9) along with twelve known co-isolated congeners. The detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11R,17S) (1) is described. Their chemical characterization was achieved by HRMS and integrated 1D and 2D NMR (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. For the first time, a complete assignment of the absolute configurations for stereogenic centers C-11/17 of the known members (11R,17S) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of chemical modifications, Mosher's technology, and ECD spectroscopy. Consequently, the absolute configurations of all our new isolated compounds 2-9 were determined by the combination of NMR, Mosher's method, ECD comparison, and chemical modifications. Interestingly, compounds 2-7 were obtained by chemical transformation of the major compound 11-epi-fistularin-3 (1). Evaluation for acetylcholinesterase inhibition (AChE), DNA methyltransferase 1 (DNMT1) modulating activity and antifouling activities using marine bacterial strains are also presented. specialized sponge Verongiida Suberea clavata bromotyrosine fistularin-3 acetylcholinesterase inhibition antifouling PACIFIQUE 035 19 3 143 [22 ] 2021 https://www.documentation.ird.fr/hor/fdi:010081163 10.3390/md19030143 [F B010081163] https://www.documentation.ird.fr/hor/fdi:010081163 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-05/010081163.pdf IRD - Base Horizon / Pleins textes 2021-05-17 2025-02-24 fdi:010081163 fre