Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Marine Drugs 143 [22 ] sponge Verongiida Suberea clavata bromotyrosine fistularin-3 acetylcholinesterase inhibition antifouling PACIFIQUE SALOMON ILES 2021 fdi:010081163 ENG Marine Drugs ISI:000633826900001 3 10.3390/md19030143 https://www.documentation.ird.fr/hor/fdi:010081163 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-05/010081163.pdf 19 Horizon (IRD) Chemical investigation of the South-Pacific marine sponge Suberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1-8 (2-9) along with twelve known co-isolated congeners. The detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11R,17S) (1) is described. Their chemical characterization was achieved by HRMS and integrated 1D and 2D NMR (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. For the first time, a complete assignment of the absolute configurations for stereogenic centers C-11/17 of the known members (11R,17S) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of chemical modifications, Mosher's technology, and ECD spectroscopy. Consequently, the absolute configurations of all our new isolated compounds 2-9 were determined by the combination of NMR, Mosher's method, ECD comparison, and chemical modifications. Interestingly, compounds 2-7 were obtained by chemical transformation of the major compound 11-epi-fistularin-3 (1). Evaluation for acetylcholinesterase inhibition (AChE), DNA methyltransferase 1 (DNMT1) modulating activity and antifouling activities using marine bacterial strains are also presented. 035 UR195 / UR241