Bioactive bromotyrosine derivatives from the Pacific marine sponge Suberea clavata (Pulitzer-Finali, 1982) Moriou, C. Lacroix, D. /Petek, Sylvain El-Demerdash, A. Trepos, R. Leu, T. M. Florean, C. Diederich, M. Hellio, C. /Debitus, Cécile Al-Mourabit, A. sponge Verongiida Suberea clavata bromotyrosine fistularin-3 acetylcholinesterase inhibition antifouling Chemical investigation of the South-Pacific marine sponge Suberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1-8 (2-9) along with twelve known co-isolated congeners. The detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11R,17S) (1) is described. Their chemical characterization was achieved by HRMS and integrated 1D and 2D NMR (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. For the first time, a complete assignment of the absolute configurations for stereogenic centers C-11/17 of the known members (11R,17S) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of chemical modifications, Mosher's technology, and ECD spectroscopy. Consequently, the absolute configurations of all our new isolated compounds 2-9 were determined by the combination of NMR, Mosher's method, ECD comparison, and chemical modifications. Interestingly, compounds 2-7 were obtained by chemical transformation of the major compound 11-epi-fistularin-3 (1). Evaluation for acetylcholinesterase inhibition (AChE), DNA methyltransferase 1 (DNMT1) modulating activity and antifouling activities using marine bacterial strains are also presented. 2021 text https://www.documentation.ird.fr/hor/fdi:010081163 fdi:010081163 Moriou C., Lacroix D., Petek Sylvain, El-Demerdash A., Trepos R., Leu T. M., Florean C., Diederich M., Hellio C., Debitus Cécile, Al-Mourabit A.. Bioactive bromotyrosine derivatives from the Pacific marine sponge Suberea clavata (Pulitzer-Finali, 1982). 2021, 19 (3), 143 [22 ] EN PACIFIQUE