@article{fdi:010081163,
  title = {{B}ioactive bromotyrosine derivatives from the {P}acific marine sponge {S}uberea clavata ({P}ulitzer-{F}inali, 1982)},
  author = {{M}oriou, {C}. and {L}acroix, {D}. and {P}etek, {S}ylvain and {E}l-{D}emerdash, {A}. and {T}repos, {R}. and {L}eu, {T}. {M}. and {F}lorean, {C}. and {D}iederich, {M}. and {H}ellio, {C}. and {D}ebitus, {C}{\'e}cile and {A}l-{M}ourabit, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}hemical investigation of the {S}outh-{P}acific marine sponge {S}uberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1-8 (2-9) along with twelve known co-isolated congeners. {T}he detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11{R},17{S}) (1) is described. {T}heir chemical characterization was achieved by {HRMS} and integrated 1{D} and 2{D} {NMR} (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. {F}or the first time, a complete assignment of the absolute configurations for stereogenic centers {C}-11/17 of the known members (11{R},17{S}) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of chemical modifications, {M}osher's technology, and {ECD} spectroscopy. {C}onsequently, the absolute configurations of all our new isolated compounds 2-9 were determined by the combination of {NMR}, {M}osher's method, {ECD} comparison, and chemical modifications. {I}nterestingly, compounds 2-7 were obtained by chemical transformation of the major compound 11-epi-fistularin-3 (1). {E}valuation for acetylcholinesterase inhibition ({AC}h{E}), {DNA} methyltransferase 1 ({DNMT}1) modulating activity and antifouling activities using marine bacterial strains are also presented.},
  keywords = {sponge ; {V}erongiida ; {S}uberea clavata ; bromotyrosine ; fistularin-3 ; acetylcholinesterase inhibition ; antifouling ; {PACIFIQUE} ; {SALOMON} {ILES}},
  booktitle = {},
  journal = {{M}arine {D}rugs},
  volume = {19},
  numero = {3},
  pages = {143 [22 ]},
  year = {2021},
  DOI = {10.3390/md19030143},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081163},
}