@article{fdi:010081107,
  title = {{S}ynthesis and antiviral evaluation of (1,4-disubstituted-1,2,3-triazol)-(e)-2-methyl-but-2-{E}nyl nucleoside phosphonate prodrugs},
  author = {{A}buduaini, {T}. and {R}oy, {V}. and {M}arlet, {J}. and {G}audy-{G}raffin, {C}. and {B}rand, {D}. and {B}aronti, {C}{\'e}cile and {T}ouret, {F}. and {C}outard, {B}. and {M}c{B}rayer, {T}. {R}. and {S}chinazi, {R}. {F}. and {A}grofoglio, {L}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} series of hitherto unknown (1,4-disubstituted-1,2,3-triazol)-({E})-2-methyl-but-2-enyl nucleosides phosphonate prodrugs bearing 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as the key synthetic step. {A}ll novel compounds were evaluated for their antiviral activities against {HBV}, {HIV} and {SARS}-{C}o{V}-2. {A}mong these molecules, only compound 15j, a hexadecyloxypropyl ({HDP})/(isopropyloxycarbonyl-oxymethyl)-ester ({POC}) prodrug, showed activity against {HBV} in {H}uh7 cell cultures with 62% inhibition at 10 mu {M}, without significant cytotoxicity ({IC}50 = 66.4 mu {M} in {H}ep{G}2 cells, {IC}50 = 43.1 mu {M} in {H}ep{G}2 cells) at 10 mu {M}.},
  keywords = {nucleosides ; olefin cross metathesis ; ultrasound ; copper-catalyzed ; azide-alkyne cycloaddition ({C}u{AAC}) ; antiviral properties ; {HBV} ; {HIV} ; {SARS}-{C}o{V}-2},
  booktitle = {},
  journal = {{M}olecules},
  volume = {26},
  numero = {5},
  pages = {1493 [18 p.]},
  year = {2021},
  DOI = {10.3390/molecules26051493},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081107},
}