@article{fdi:010081098,
  title = {{A}t least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions},
  author = {{S}imsek, {C}. and {C}orman, {V}. {M}. and {E}verling, {H}. {U}. and {L}ukashev, {A}. {N}. and {R}asche, {A}. and {M}aganga, {G}. {D}. and {B}inger, {T}. and {J}ansen, {D}. and {B}eller, {L}. and {D}eboutte, {W}. and {G}loza-{R}ausch, {F}. and {S}eebens-{H}oyer, {A}. and {Y}ordanov, {S}. and {S}ylverken, {A}. and {O}ppong, {S}. and {S}arkodie, {Y}. {A}. and {V}allo, {P}. and {L}eroy, {E}ric and {B}ourgarel, {M}. and {Y}inda, {K}. {C}. and {V}an {R}anst, {M}. and {D}rosten, {C}. and {D}rexler, {J}. {F}. and {M}atthijnssens, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ats host many viruses pathogenic to humans, and increasing evidence suggests that rotavirus {A} ({RVA}) also belongs to this list. {R}otaviruses cause diarrheal disease in many mammals and birds, and their segmented genomes allow them to reassort and increase their genetic diversity. {E}ighteen out of 2,142 bat fecal samples (0.8%) collected from {E}urope, {C}entral {A}merica, and {A}frica were {PCR}-positive for {RVA}, and 11 of those were fully characterized using viral metagenomics. {U}pon contrasting their genomes with publicly available data, at least 7 distinct bat {RVA} genotype constellations ({GC}s) were identified, which included evidence of reassortments and 6 novel genotypes. {S}ome of these constellations are spread across the world, whereas others appear to be geographically restricted. {O}ur analyses also suggest that several unusual human and equine {RVA} strains might be of bat {RVA} origin, based on their phylogenetic clustering, despite various levels of nucleotide sequence identities between them. {A}lthough {SA}11 is one of the most widely used reference strains for {RVA} research and forms the backbone of a reverse genetics system, its origin remained enigmatic. {R}emarkably, the majority of the genotypes of {SA}11-like strains were shared with {G}abonese bat {RVA}s, suggesting a potential common origin. {O}verall, our findings suggest an underexplored genetic diversity of {RVA}s in bats, which is likely only the tip of the iceberg. {I}ncreasing contact between humans and bat wildlife will further increase the zoonosis risk, which warrants closer attention to these viruses. {IMPORTANCE} {T}he increased research on bat coronaviruses after severe acute respiratory syndrome coronavirus ({SARS}-{C}o{V}) and {M}iddle {E}ast respiratory syndrome coronavirus ({MERS}-{C}o{V}) allowed the very rapid identification of {SARS}-{C}o{V}-2. {T}his is an excellent example of the importance of knowing viruses harbored by wildlife in general, and bats in particular, for global preparedness against emerging viral pathogens. {T}he current effort to characterize bat rotavirus strains from 3 continents sheds light on the vast genetic diversity of rotaviruses and also hints at a bat origin for several atypical rotaviruses in humans and animals, implying that zoonoses of bat rotaviruses might occur more frequently than currently realized.},
  keywords = {{V}iral metagenomics ; bat rotavirus ; rotavirus genetic diversity ; {SA}11 ; zoonosis ; {BULGARIE} ; {ROUMANIE} ; {ALLEMAGNE} ; {GABON} ; {GHANA} ; {COSTA} {RICA} ; {MONDE}},
  booktitle = {},
  journal = {m{B}io},
  volume = {12},
  numero = {1},
  pages = {e02755--20 [17 p.]},
  ISSN = {2150-7511},
  year = {2021},
  DOI = {10.1128/m{B}io.02755-20},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081098},
}