%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Challenger, J. D.
%A Mesa, D. O.
%A Da, D. F.
%A Yerbanga, R. S.
%A Lefèvre, Thierry
%A Cohuet, Anna
%A Churcher, T. S.
%T Predicting the public health impact of a malaria transmission-blocking vaccine
%D 2021
%L fdi:010081089
%G ENG
%J Nature Communications
%@ 2041-1723
%K BURKINA FASO
%M ISI:000627441800001
%N 1
%P 1494 [12 ]
%R 10.1038/s41467-021-21775-3
%U https://www.documentation.ird.fr/hor/fdi:010081089
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers21-03/010081089.pdf
%V 12
%W Horizon (IRD)
%X Transmission-blocking vaccines that interrupt malaria transmission from humans to mosquitoes are being tested in early clinical trials. The activity of such a vaccine is commonly evaluated using membrane-feeding assays. Understanding the field efficacy of such a vaccine requires knowledge of how heavily infected wild, naturally blood-fed mosquitoes are, as this indicates how difficult it will be to block transmission. Here we use data on naturally infected mosquitoes collected in Burkina Faso to translate the laboratory-estimated activity into an estimated activity in the field. A transmission dynamics model is then utilised to predict a transmission-blocking vaccine's public health impact alongside existing interventions. The model suggests that school-aged children are an attractive population to target for vaccination. Benefits of vaccination are distributed across the population, averting the greatest number of cases in younger children. Utilising a transmission-blocking vaccine alongside existing interventions could have a substantial impact against malaria. Malaria transmission-blocking vaccines are in development, but roll-out strategies have not been assessed. Here, the authors show that transmission-blocking activity is likely to be higher in the field than in laboratory conditions, and that school-aged children are an important group to target.
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