@article{fdi:010081089,
  title = {{P}redicting the public health impact of a malaria transmission-blocking vaccine},
  author = {{C}hallenger, {J}. {D}. and {M}esa, {D}. {O}. and {D}a, {D}. {F}. and {Y}erbanga, {R}. {S}. and {L}ef{\`e}vre, {T}hierry and {C}ohuet, {A}nna and {C}hurcher, {T}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}ransmission-blocking vaccines that interrupt malaria transmission from humans to mosquitoes are being tested in early clinical trials. {T}he activity of such a vaccine is commonly evaluated using membrane-feeding assays. {U}nderstanding the field efficacy of such a vaccine requires knowledge of how heavily infected wild, naturally blood-fed mosquitoes are, as this indicates how difficult it will be to block transmission. {H}ere we use data on naturally infected mosquitoes collected in {B}urkina {F}aso to translate the laboratory-estimated activity into an estimated activity in the field. {A} transmission dynamics model is then utilised to predict a transmission-blocking vaccine's public health impact alongside existing interventions. {T}he model suggests that school-aged children are an attractive population to target for vaccination. {B}enefits of vaccination are distributed across the population, averting the greatest number of cases in younger children. {U}tilising a transmission-blocking vaccine alongside existing interventions could have a substantial impact against malaria. {M}alaria transmission-blocking vaccines are in development, but roll-out strategies have not been assessed. {H}ere, the authors show that transmission-blocking activity is likely to be higher in the field than in laboratory conditions, and that school-aged children are an important group to target.},
  keywords = {{BURKINA} {FASO}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {12},
  numero = {1},
  pages = {1494 [12 p.]},
  ISSN = {2041-1723},
  year = {2021},
  DOI = {10.1038/s41467-021-21775-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081089},
}