Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones

Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones Salas-Ambrosio P. auteur aut IRD Tronnet A. auteur aut IRD Since M. auteur aut IRD Bourgeade-Delmas Sandra auteur aut IRD Stigliani J. L. auteur aut IRD Vax A. auteur aut IRD Lecommandoux S. auteur aut IRD Dupuy B. auteur aut IRD Verhaeghe P. auteur aut IRD Bonduelle C. auteur aut IRD text journalArticle eng text/pdf born digital access Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(alpha-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections. specialized 020 050 Journal of the American Chemical Society 143 10 3697-3702 2021 0002-7863 https://www.documentation.ird.fr/hor/fdi:010081087 10.1021/jacs.0c13231 0002-7863 [F B010081087] https://www.documentation.ird.fr/hor/fdi:010081087 https://www.documentation.ird.fr/intranet/publi/2021/03/010081087.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2021-04-01 2025-02-24 fdi:010081087 fre