Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones Journal of the American Chemical Society 3697-3702 2021 fdi:010081087 ENG Journal of the American Chemical Society 0002-7863 ISI:000630322300007 10 10.1021/jacs.0c13231 https://www.documentation.ird.fr/hor/fdi:010081087 https://www.documentation.ird.fr/intranet/publi/2021/03/010081087.pdf 143 Horizon (IRD) Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(alpha-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections. 020 ; 050 UR152