Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones Salas-Ambrosio, P. Tronnet, A. Since, M. /Bourgeade-Delmas, Sandra Stigliani, J. L. Vax, A. Lecommandoux, S. Dupuy, B. Verhaeghe, P. Bonduelle, C. Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(alpha-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections. 2021 text https://www.documentation.ird.fr/hor/fdi:010081087 fdi:010081087 Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas Sandra, Stigliani J. L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C.. Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones. 2021, 143 (10), 3697-3702 EN