@article{fdi:010081049,
  title = {{L}ower mgp{B} diversity in macrolide-resistant {M}ycoplasma genitalium infecting men visiting two sexually transmitted infection clinics in {M}ontpellier, {F}rance},
  author = {{G}uiraud, {J}. and {L}ounnas, {M}anon and {B}oissiere, {A}. and {L}e {R}oy, {C}. and {E}lguero, {E}ric and {B}anuls, {A}nne-{L}aure and {B}ebear, {C}. and {G}odreuil, {S}. and {P}ereyre, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {M}en engaged in high-risk sexual behaviour, such as {MSM}, are {L}ikely to be infected by resistant {M}ycoplasma genitalium strains. {U}nderstanding the transmission dynamics is challenging. {W}e aimed to investigate the molecular epidemiology of {M}. genitalium in men visiting sexually transmitted infection ({STI}) clinics. {P}atients and methods: {B}etween {J}une 2017 and {F}ebruary 2018, 95 {M}. genitalium-positive specimens from 78 men, including 76.9% {MSM}, visiting two {STI} clinics in {M}ontpellier, {F}rance, were analysed for {SNP}s in the mgp{B} adhesin gene and number of tandem repeats in the {MG}309 gene. {M}acrolide and fluoroquinolone resistance were determined. {T}yping results were compared with antibiotic resistance, sexual behaviour, sampling site, {HIV} pre-exposure prophylaxis ({P}r{EP}) usage and {HIV} status. {R}esults: {T}hirty-eight mgp{B} {ST}s were identified, including 23 new {ST}s, with {ST}4 being most prevalent. {T}he mgp{B}/{MG}_309 typing method identified 52 genetic profiles, resulting in a discriminatory index of 0.979. {M}acrolide and fluoroquinolone resistance-associated mutations were detected in 58.3% and 10.8% of patients, respectively. {T}he macrolide resistance rate was higher among {MSM} than among men who have sex with women only (68.4% versus 9.1%; adjusted {OR}, 1.57; 95% {CI}, 1.13-2.18; {P}=0.007). {A} {L}ower mgp{B} diversity of 0.870 was found among macrolide-resistant strains in comparison with 0.978 in macrolide-susceptible strains, with an overrepresentation of mgp{B} {ST}62 and {ST}153. {C}onclusions: {A}lthough macrolide resistance spread appears polyclonal in {M}. genitalium, the {L}ower diversity of mgp{B} types among macrolide-resistant strains may reflect the easier spread of a few specific mgp{B} types or the occurrence of sexual networks among {MSM}.},
  keywords = {{FRANCE} ; {MONTPELLIER}},
  booktitle = {},
  journal = {{J}ournal of {A}ntimicrobial {C}hemotherapy},
  volume = {76},
  numero = {1},
  pages = {43--47},
  ISSN = {0305-7453},
  year = {2021},
  DOI = {10.1093/jac/dkaa410},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081049},
}