%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Crava, C. M.
%A Varghese, F. S.
%A Pischedda, E.
%A Halbach, R.
%A Palatini, U.
%A Marconcini, M.
%A Gasmi, L.
%A Redmond, S.
%A Afrane, Y.
%A Ayala, Diego
%A Paupy, Christophe
%A Carballar-Lejarazu, R.
%A Miesen, P.
%A van Rij, R. P.
%A Bonizzoni, M.
%T Population genomics in the arboviral vector Aedes aegypti reveals the genomic architecture and evolution of endogenous viral elements
%D 2021
%L fdi:010080980
%G ENG
%J Molecular Ecology
%@ 0962-1083
%K Aedes aegypti ; endogenous viral elements ; mosquito genomes ; piRNA ; cluster
%M ISI:000620198300001
%N 7
%P 1594-1611
%R 10.1111/mec.15798
%U https://www.documentation.ird.fr/hor/fdi:010080980
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers21-03/010080980.pdf
%V 30
%W Horizon (IRD)
%X Horizontal gene transfer from viruses to eukaryotic cells is a pervasive phenomenon. Somatic viral integrations are linked to persistent viral infection whereas integrations into germline cells are maintained in host genomes by vertical transmission and may be co-opted for host functions. In the arboviral vector Aedes aegypti, an endogenous viral element from a nonretroviral RNA virus (nrEVE) was shown to produce PIWI-interacting RNAs (piRNAs) to limit infection with a cognate virus. Thus, nrEVEs may constitute a heritable, sequence-specific mechanism for antiviral immunity, analogous to piRNA-mediated silencing of transposable elements. Here, we combine population genomics and evolutionary approaches to analyse the genomic architecture of nrEVEs in A. aegypti. We conducted a genome-wide screen for adaptive nrEVEs and searched for novel population-specific nrEVEs in the genomes of 80 individual wild-caught mosquitoes from five geographical populations. We show a dynamic landscape of nrEVEs in mosquito genomes and identified five novel nrEVEs derived from two currently circulating viruses, providing evidence of the environmental-dependent modification of a piRNA cluster. Overall, our results show that virus endogenization events are complex with only a few nrEVEs contributing to adaptive evolution in A. aegypti.
%$ 052