@article{fdi:010080980,
  title = {{P}opulation genomics in the arboviral vector {A}edes aegypti reveals the genomic architecture and evolution of endogenous viral elements},
  author = {{C}rava, {C}. {M}. and {V}arghese, {F}. {S}. and {P}ischedda, {E}. and {H}albach, {R}. and {P}alatini, {U}. and {M}arconcini, {M}. and {G}asmi, {L}. and {R}edmond, {S}. and {A}frane, {Y}. and {A}yala, {D}iego and {P}aupy, {C}hristophe and {C}arballar-{L}ejarazu, {R}. and {M}iesen, {P}. and van {R}ij, {R}. {P}. and {B}onizzoni, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}orizontal gene transfer from viruses to eukaryotic cells is a pervasive phenomenon. {S}omatic viral integrations are linked to persistent viral infection whereas integrations into germline cells are maintained in host genomes by vertical transmission and may be co-opted for host functions. {I}n the arboviral vector {A}edes aegypti, an endogenous viral element from a nonretroviral {RNA} virus (nr{EVE}) was shown to produce {PIWI}-interacting {RNA}s (pi{RNA}s) to limit infection with a cognate virus. {T}hus, nr{EVE}s may constitute a heritable, sequence-specific mechanism for antiviral immunity, analogous to pi{RNA}-mediated silencing of transposable elements. {H}ere, we combine population genomics and evolutionary approaches to analyse the genomic architecture of nr{EVE}s in {A}. aegypti. {W}e conducted a genome-wide screen for adaptive nr{EVE}s and searched for novel population-specific nr{EVE}s in the genomes of 80 individual wild-caught mosquitoes from five geographical populations. {W}e show a dynamic landscape of nr{EVE}s in mosquito genomes and identified five novel nr{EVE}s derived from two currently circulating viruses, providing evidence of the environmental-dependent modification of a pi{RNA} cluster. {O}verall, our results show that virus endogenization events are complex with only a few nr{EVE}s contributing to adaptive evolution in {A}. aegypti.},
  keywords = {{A}edes aegypti ; endogenous viral elements ; mosquito genomes ; pi{RNA} ; cluster},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {30},
  numero = {7},
  pages = {1594--1611},
  ISSN = {0962-1083},
  year = {2021},
  DOI = {10.1111/mec.15798},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080980},
}