@article{fdi:010080913,
  title = {{D}ifferential immune gene expression associated with contemporary range expansion in two invasive rodents in {S}enegal},
  author = {{C}harbonnel, {N}. and {G}alan, {M}. and {T}atard, {C}. and {L}oiseau, {A}. and {D}iagne, {C}. and {D}alecky, {A}mbroise and {P}arrinello, {H}. and {R}ialle, {S}. and {S}everac, {D}. and {B}rouat, {C}arine},
  editor = {},
  language = {{ENG}},
  abstract = {{B}iological invasions are major anthropogenic changes associated with threats to biodiversity and health. {H}owever, what determines the successful establishment and spread of introduced populations remains unclear. {H}ere, we explore several hypotheses linking invasion success and immune phenotype traits, including those based on the evolution of increased competitive ability concept. {W}e compared gene expression profiles between anciently and recently established populations of two major invading species, the house mouse {M}us musculus domesticus and the black rat {R}attus rattus, in {S}enegal ({W}est {A}frica). {T}ranscriptome analyses identified differential expression between anciently and recently established populations for 364 mouse genes and 83 rat genes. {A}ll immune-related genes displaying differential expression along the mouse invasion route were overexpressed at three of the four recently invaded sites studied. {C}omplement activation pathway genes were overrepresented among these genes. {B}y contrast, no particular immunological process was found to be overrepresented among the differentially expressed genes of black rat. {C}hanges in transcriptome profiles were thus observed along invasion routes, but with different specific patterns between the two invasive species. {T}hese changes may be driven by increases in infection risks at sites recently invaded by the house mouse, and by stochastic events associated with colonization history for the black rat. {T}hese results constitute a first step toward the identification of immune eco-evolutionary processes potentially involved in the invasion success of these two rodent species.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {10},
  numero = {1},
  pages = {18257 [13 p.]},
  ISSN = {2045-2322},
  year = {2020},
  DOI = {10.1038/s41598-020-75060-2},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080913},
}