Mahamat O. O. auteur aut IRD Kempf M. auteur aut IRD Lounnas Manon auteur aut IRD Tidjani A. auteur aut IRD Hide M. auteur aut IRD Benavides J. A. auteur aut IRD Carriere C. auteur aut IRD Banuls Anne-Laure auteur aut IRD Jean-Pierre H. auteur aut IRD Ouedraogo A. S. auteur aut IRD Dumont Y. auteur aut IRD Godreuil S. auteur aut IRD text journalArticle eng text/pdf born digital access Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) are widespread. Here we used the 'One Health' approach to determine knowledge gaps on ESBL-E and CPE in West and Central Africa. We searched all articles on ESBL-E and CPE in these African regions published in PubMed, African Journals Online and Google Scholar from 2000 onwards. Among the 1201 articles retrieved, we selected 165 studies (West Africa, 118; Central Africa, 47) with data from 22 of the 26 West and Central Africa countries. Regarding the settings, 136 articles focused only on humans (carriage and/or infection), 6 articles on humans and animals, 13 on animals, 1 on humans and the environment, 8 on the environment and 1 on humans, animals and environments. ESBL-E prevalence ranged from 11-72% in humans and 7-79% in aquatic environments (wastewater). In animals, ESBL-E prevalence hugely varied: 0% in cattle, 11-36% in chickens, 20% in rats, 21-71% in pigs and 32-75% in dogs. The blu(CTX-M-15) gene was the predominant ESBL-encoding gene and was associated with plasmids of incompatibility groups F, H, K, Y, N, II and R. CPE were studied only in humans. Class B metallo-beta-lactamases (NDM) and class D oxacillinases (OXA-48 and OXA-181) were the most common carbapenemases. Our results show major knowledge gaps, particularly on ESBL and CPE in animals and the environment, that might limit antimicrobial resistance management in these regions. The results also emphasise the urgent need to improve active surveillance programmes in each country and to support antimicrobial stewardship. specialized ESBL Carbapenemase Central and West Africa Enterobacteriaceae Data Systematic review AFRIQUE CENTRALE AFRIQUE DE L'OUESt 050 084 020 080 57 1 106203 [9 p.] 2021 0924-8579 https://www.documentation.ird.fr/hor/fdi:010080616 10.1016/j.ijantimicag.2020.106203 0924-8579 [F B010080616] https://www.documentation.ird.fr/hor/fdi:010080616 https://www.documentation.ird.fr/intranet/publi/2021/02/010080616.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2021-03-10 2025-02-24 fdi:010080616 fre