@article{fdi:010080576,
  title = {{E}vidence that seasonal malaria chemoprevention with {SPAQ} influences blood and pre-erythrocytic stage antibody responses of {P}lasmodium falciparum infections in {N}iger},
  author = {{M}oustapha, {L}. {M}. and {A}damou, {R}. and {I}brahim, {M}. {L}. and {P}adounou, {M}. {A}. {L}. and {D}iallo, {A}. and {C}ourtin, {D}avid and {T}esta, {J}. and {N}diaye, {J}. {L}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}n endemic areas, children develop slowly and naturally anti-{P}lasmodium antibodies and become semi-immune. {S}easonal {M}alaria {C}hemoprevention ({SMC}) with sulfadoxine-pyrimethamine + amodiaquine ({SPAQ}) is a new strategy to reduce malaria morbidity in {W}est {A}frican young children. {H}owever, {SMC} may impact on the natural acquisition of anti-{P}lasmodium immunity. {T}his paper evaluates the effect of {SMC} with {SPAQ} on antibody concentration in young children from {N}iger. {M}ethods {T}his research was conducted in areas benefitting from {SMC} since 2014 ({Z}inder district), without {SMC} ({D}osso district), and with 1 year of {SMC} since 2016 ({G}aya district). {T}o assess the relationship between {SMC} and {P}lasmodium falciparum {I}g{G} antibody responses, the total antibody concentrations against two {P}. falciparum asexual stage vaccine candidate antigens, circumsporozoite protein ({CSP}) and glutamate-rich protein {R}2 ({GLURP}-{R}2), in children aged 3 to 59 months across the three areas were compared. {A}ntibody concentrations are quantified using an enzyme-linked immunosorbent assay on the elution extracted from positive and negative malaria {R}apid {D}iagnostic {T}est cassettes. {R}esults {T}he analysis concerns two hundred and twenty-nine children aged from 3 to 59 months: 71 in {Z}inder, 77 in {D}osso, and 81 in {G}aya. {I}n {Z}inder ({CSP} = 17.5 mu g/ml and {GLURP}-{R}2 = 14.3 mu g/ml) median antibody concentration observed are higher than in {G}aya ({CSP} = 7.7 mu g/ml and {GLURP}-{R}2 = 6.5 mu g/ml) and {D}osso ({CSP} = 4.5 mu g/ml and {GLURP}-{R}2 = 3.6 mu g/ml) (p < 0.0001). {C}onclusion {T}he research reveals some evidences which show that seasonal malaria chemoprevention with {SPAQ} has an effect on blood stage antibody responses and pre-erythrocytic stage of {P}. falciparum infections in {N}iger. {I}ncreased antibody titres with increased {SMC}/{SPAQ} implementation. {T}his contradicts hypothesis that {SMC}/{SPAQ} could reduce immunity to erythrocyte and liver-stage antigens. {F}urther studies are necessary to provide better understanding of the {SMC} effect on malaria immunity.},
  keywords = {{S}easonal malaria chemoprevention ; {I}mmunity ; {A}ntibody ; {CSP} ; {GLURP}-{R}2 ; {P} falciparum ; {NIGER}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {20},
  numero = {1},
  pages = {1 [8 p.]},
  year = {2021},
  DOI = {10.1186/s12936-020-03550-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080576},
}