@article{fdi:010080575,
  title = {{S}usceptibility to {P}lasmodium falciparum malaria : influence of combined polymorphisms of {I}g{G}3 {G}m allotypes and {F}c gamma receptors {IIA}, {IIIA}, and iiib},
  author = {{F}all, {J}.{A}.{K}. and {D}echavanne, {C}{\'e}lia and {S}abbagh, {A}. and {G}uitard, {E}. and {M}ilet, {J}acqueline and {G}arcia, {A}ndr{\'e} and {D}ugoujon, {J}. {M}. and {C}ourtin, {D}avid and {M}igot {N}abias, {F}lorence},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he binding of immunoglobulin ({I}g) to {F}c gamma receptors ({F}cg{R}) at the immune cell surface is an important step to initiate immunological defense against malaria. {H}owever, polymorphisms in receptors and/or constant regions of the {I}g{G} heavy chains may modulate this binding. {H}ere, we investigated whether polymorphisms located in {F}cg{R} and constant regions of the heavy chain of {I}g{G} are associated with susceptibility to {P}. falciparum malaria. {F}or this purpose, a clinical and parasitological follow-up on malaria was conducted among 656 infants in southern {B}enin. {G}3m allotypes (from total {I}g{G}3) were determined by a serological method of hemagglutination inhibition. {F}cg{RIIA} 131{R}/{H} and {F}cg{RIIIA} 176{F}/{V} genotypes were determined using the {T}aq{M}an method and {F}cg{RIIIB} {NA}1/{NA}2 genotypes were assessed by polymerase chain reaction using allele-specific primers. {A}ssociation analyses between the number of malaria infections during the follow-up and polymorphisms in {I}g{G} {G}3m allotypes and {F}cg{R} were studied independently by zero inflated binomial negative regression. {T}he influence of combinations of {G}3m allotypes and {F}cg{RIIA}/{F}cg{RIIIA}/{F}cg{RIIIB} polymorphisms on the number of {P}. falciparum infections, and their potential interaction with environmental exposure to malaria was assessed by using the generalized multifactor dimensionality reduction ({GMDR}) method. {R}esults showed that individual carriage of {G}3m24 single allotype and of {G}3m5,6,10,11,13,14,24 phenotype was independently associated with a high risk of malaria infection. {A} risk effect for {G}3m6 was observed only under high environmental exposure. {F}cg{RIIIA} 176{VV} single genotype and combined carriage of {F}cg{RIIA} 131{RH}/{F}cg{RIIIA} 176{VV}/{F}cg{RIIIB} {NA}1{NA}2, {F}cg{RIIA} 131{HH}/{F}cg{RIIIA} 176{FF}/{F}cg{RIIIB} {NA}1{NA}1, {F}cg{RIIA} 131{HH}/{F}cg{RIIIA} 176{VV}/{F}cg{RIIIB} {NA}2{NA}2 and {F}cg{RIIA} 131{HH}/{F}cg{RIIIA} 176{VV}/{F}cg{RIIIB} {NA}1{NA}2 genotypes were related to a high number of malaria infections. {T}he risk was accentuated for {F}cg{RIIIA} 176{VV} when considering the influence of environmental exposure to malaria. {F}inally, the {GMDR} analysis including environmental exposure showed strengthened associations with a malaria risk when {F}cg{RIIA}/{F}cg{RIIIA}/{F}cg{RIIIB} genotypes were combined to {G}3m5,6,11,24 and {G}3m5,6,10,11,13,15,24 phenotypes or {G}3m10 and {G}3m13 single allotypes. {O}ur results highlight the relevance of studying {I}g{G} heavy chain and {F}cg{R} polymorphisms, independently as well as in combination, in relation to the individual susceptibility to {P}. falciparum infection. {T}he intensity of individual exposure to mosquito bites was demonstrated to impact the relationships found.},
  keywords = {malaria ; {I}g{G} polymorphism ; {G}m allotypes ; {F}c gamma receptor ; {B}enin ; generalized multifactor dimensionality reduction ; {BENIN}},
  booktitle = {},
  journal = {{F}rontiers in {I}mmunology},
  volume = {11},
  numero = {},
  pages = {608016 [15 ]},
  ISSN = {1664-3224},
  year = {2020},
  DOI = {10.3389/fimmu.2020.608016},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080575},
}