@article{fdi:010080433,
  title = {{B}ioactive isocedrenes from {P}erezia multiflora},
  author = {{B}ourgeade-{D}elmas, {S}andra and {A}ndre-{B}arres, {C}. and {L}ucas, {J}. and {T}rinel, {M}. and {P}areja, {D}. {C}. and {J}ullian, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{F}our isocedrenes ( 1 - 4 ), including one new compound ( 2 ), were isolated from an ethanolic extract of the aerial parts of {P}erezia multiflora by bioactivity-guided fractionation. {F}or compounds 1 and 3 , a revised stereochemical assignment is proposed based on molecular modeling studies using {DFT}-{NMR} calculations. {A}ntiparasitic activity of the four compounds was evaluated using an in vitro culture of {P}lasmodium falciparum and axenic amastigotes of {L}eishmania infantum. {IC} (50) values ranged from 0.81 to 16.1 mu {M} ( {P}. falciparum ) and 0.16 to 2.03 mu {M} ( {L}. infantum ). {T}oxicity was evaluated against {J}774{A}.1 mouse macrophages or human macrophages generated from {THP}-1 monocytic cells ({IC} (50) values ranging from 0.16 to 2.64 mu {M}). {C}ompound 4 exhibited weak selectivity against {P}. falciparum with a selectivity index ({SI} = {CC} (50) /{IC} (50) ) of 3. {N}o selectivity was observed for compounds 1 - 3 against both parasites.},
  keywords = {{P}erezia multiflora ; {A}steraceae ; isocedrenes ; sesquiterpenes ; {P}lasmodium ; {L}eishmania},
  booktitle = {},
  journal = {{P}lanta {M}edica},
  volume = {87},
  numero = {3},
  pages = {201--208},
  ISSN = {0032-0943},
  year = {2021},
  DOI = {10.1055/a-1298-4706},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080433},
}