@article{fdi:010080399,
  title = {{N}itric oxide reactivity accounts for {N}-nitroso-ciprofloxacin formation under nitrate-reducing conditions},
  author = {{B}rienza, {M}. and {M}anasfi, {R}. and {S}auvetre, {A}. and {C}hiron, {S}erge},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he formation of {N}-nitroso-ciprofloxacin ({CIP}) was investigated both in wastewater treatment plants including nitrification/denitrification stages and in sludge slurry experiments under denitrifying conditions. {T}he analysis of biological wastewater treatment plant effluents by {K}endrick mass defect analysis and liquid chromatography - high resolution - mass spectrometry ({LC}-{HRMS}) revealed the occurrence of {N}-nitroso-{CIP} and {N}-nitroso-hydrochlorothiazide at concentration levels of 34 +/- 3 ng/{L} and 71 +/- 6 ng/{L}, respectively. {I}n laboratory experiments and dark conditions, produced {N}-nitroso-{CIP} concentrations reached a plateau during the course of biodegradation experiments. {A} mass balance was achieved after identification and quantification of several transformation products by {LC}-{HRMS}. {N}-nitroso-{CIP} accounted for 14.3% of the initial {CIP} concentration (20 mu g/{L}) and accumulated against time. {T}he use of 4,5-diaminofluorescein diacetate and superoxide dismutase as scavengers for in situ production of nitric oxide and superoxide radical anion respectively, revealed that the mechanisms of formation of {N}-nitroso-{CIP} likely involved a nitrosation pathway through the formation of peroxynitrite and another one through codenitrification processes, even though the former one appeared to be prevalent. {T}his work extended the possible sources of {N}-nitrosamines by including a formation pathway relying on nitric oxide reactivity with secondary amines under activated sludge treatment.},
  keywords = {{N}-nitrosamine ; {N}-nitroso-ciprofloxacin ; {N}itric oxide ; {A}ctivated sludge ; {B}iodegradation ; {FRANCE}},
  booktitle = {},
  journal = {{W}ater {R}esearch},
  volume = {185},
  numero = {},
  pages = {116293 [8 ]},
  ISSN = {0043-1354},
  year = {2020},
  DOI = {10.1016/j.watres.2020.116293},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080399},
}