Thomas F. auteur aut IRD Elguero Eric auteur aut IRD Brodeur J. auteur aut IRD Roche Benjamin auteur aut IRD Missé Dorothée auteur aut IRD Raymond M. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Persistence of cancer over evolutionary timesis a challenging question for scientists. We explored herethe idea that cancer might result from negative trade-offs of adaptations that improve early survival and/orreproductive fitness. We focused on birth weight since thislife history trait has a genetic basis and is also associatedwith fitness benefits early in life, especially survival. Ouranalysis includes 107 to 109 countries, 46 types of cancerand various potentially confounding variables. High birthweight was associated with an elevated incidence of tencancers: kidney cancer, melanoma, multiple myeloma andpancreatic cancer, all four in both men and women, plusprostate and bladder cancers in men. These results, thoughcorrelational, suggest that antagonistic pleiotropy should beinvestigated further as a possible mechanism involved in thecausation of cancer in humans. specialized SANTE EPIDEMIOLOGIE POIDS DE NAISSANCE PHENOTYPE MODIFICATION GENETIQUE ANALYSE DE REGRESSION ETUDE COMPARATIVE CANCER MONDE 050EPID 12 ID QI 20502 [5 ] 2012 2090-7915 https://www.documentation.ird.fr/hor/fdi:010080029 10.4303/jem/Q120502 2090-7915 [F B010080029] https://www.documentation.ird.fr/hor/fdi:010080029 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-10/010080029.pdf IRD - Base Horizon / Pleins textes 2020-10-12 2020-11-12 fdi:010080029 fre