@article{fdi:010080029,
  title = {{M}alignancies and high birth weight in human : which cancers could result from antagonistic pleiotropy ?},
  author = {{T}homas, {F}. and {E}lguero, {E}ric and {B}rodeur, {J}. and {R}oche, {B}enjamin and {M}iss{\'e}, {D}oroth{\'e}e and {R}aymond, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}ersistence of cancer over evolutionary timesis a challenging question for scientists. {W}e explored herethe idea that cancer might result from negative trade-offs of adaptations that improve early survival and/orreproductive fitness. {W}e focused on birth weight since thislife history trait has a genetic basis and is also associatedwith fitness benefits early in life, especially survival. {O}uranalysis includes 107 to 109 countries, 46 types of cancerand various potentially confounding variables. {H}igh birthweight was associated with an elevated incidence of tencancers: kidney cancer, melanoma, multiple myeloma andpancreatic cancer, all four in both men and women, plusprostate and bladder cancers in men. {T}hese results, thoughcorrelational, suggest that antagonistic pleiotropy should beinvestigated further as a possible mechanism involved in thecausation of cancer in humans.},
  keywords = {{SANTE} ; {EPIDEMIOLOGIE} ; {POIDS} {DE} {NAISSANCE} ; {PHENOTYPE} ; {MODIFICATION} {GENETIQUE} ; {ANALYSE} {DE} {REGRESSION} ; {ETUDE} {COMPARATIVE} ; {CANCER} ; {MONDE}},
  booktitle = {},
  journal = {{J}ournal of {E}volutionary {M}edicine},
  volume = {12},
  numero = {},
  pages = {{ID} {QI} 20502 [5 ]},
  ISSN = {2090-7915},
  year = {2012},
  DOI = {10.4303/jem/{Q}120502},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080029},
}