@article{fdi:010080028,
  title = {{P}redominant clonal evolution leads to a close parity between gene expression profiles and subspecific phylogeny in {T}rypanosoma cruzi},
  author = {{T}elleria, {J}enny and {B}arnab{\'e}, {C}hristian and {H}ide, {M}. and {B}anuls, {A}nne-{L}aure and {T}ibayrenc, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e investigated the relationships between overall phylogenetic diversity in {T}rypanosoma cruzi evidenced by multilocus markers ({MLEE} and {RAPD}) on the one hand, and gene expression patterns, revealed by m{RNA} analysis on the other hand. {N}ineteen laboratory-cloned stocks representative of this parasite’s overall phylogenetic diversity and ecogeographical range were analyzed using random amplified differentially expressed sequences ({RADES}). {T}he bat trypanosome {T}. cruzi marinkellei was taken as outgroup. {T}he profiles obtained showed that {RADES} polymorphism cannot be considered as a simple subsample of general {RAPD} polymorphism. {I}ndeed, many {RADES} bands were not present in general {RAPD} profiles, and vice versa. {P}hylogenies obtained from {RADES} on the one hand, and {MLEE}/{RAPD} on the other hand, were very similar. {T}his suggests that in spite of the recent observation of hybrid genotypes and mosaic genes in {T}. cruzi, clonal evolution in this parasite has been preponderant enough on an evolutionary scale to carve the polymorphism on all types of {DNA} sequences, including expressed genes, although these genes are assumed to undergo natural selection pressure contrary to noncoding sequences and neutral polymorphisms.},
  keywords = {{TRYPANOSOMIASE} {HUMAINE} ; {MALADIE} {DE} {CHAGAS} ; {AGENT} {PATHOGENE} ; {GENETIQUE} {DE} {POPULATION} ; {PHYLOGENIE} ; {RECOMBINAISON} {GENETIQUE} ; {AMERIQUE} {LATINE}},
  booktitle = {},
  journal = {{M}olecular and {B}iochemical {P}arasitology},
  volume = {137},
  numero = {1},
  pages = {133--141},
  ISSN = {0166-6851},
  year = {2004},
  DOI = {10.1016/j.molbiopara.2004.05.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080028},
}